Magnesium deficiencies
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Principles & Practices of Transdermal Medicine
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Transdermal magnesium therapy
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Absorption
Medicines
can enter the body in many different ways, and they are absorbed when
they travel from the site of administration into the body’s circulation.
A drug faces its biggest hurdles during absorption. Medicines taken by
mouth are shuttled via a special blood vessel leading from the digestive
tract to the liver, where a large amount may be destroyed by metabolic
enzymes in the so-called “first-pass effect.” Other routes of drug
administration bypass the liver, entering the bloodstream directly from
or via the skin or lungs.
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When using transdermal medicines, applying more of a substance increases the amount absorbed. Penetration will generally stop when the skin is saturated. Absorption into the bloodstream is also increased if the concentration of a substance is higher and if more of the body is covered. Occluded (covered) or well-hydrated skin is easier to penetrate than non- occluded or dry skin.
There are many things that affect skin absorption. Absorption occurs by distribution around and through the cells that make up the skin. Some
[2]
absorption takes place along hair follicles or through sweat ducts. Skin thickness and barrier accessibility are different in various areas so absorption rates will vary in different parts of the body. For example, hydrocortisone (a synthetic preparation used in the treatment of inflammations, allergies, and itching) is absorbed through the skin six times better on the forehead than on the arm, and 44 times better on the scrotum.
The physical condition of the skin is a significant variable. The skin of an infant or child is more permeable than an adult. The skin over the organs in decreasing order of permeability is genitals, head and neck, trunk, arms and legs. Skin abrasion allows a locally applied substance to come directly in contact with subcutaneous tissue and blood vessels. Absorption is at a much higher rate than in healthy skin. Inflammation leaves the skin leaky and allows larger molecules to be absorbed.
There are many things that affect skin absorption. Absorption occurs by distribution around and through the cells that make up the skin. Some
[2]
absorption takes place along hair follicles or through sweat ducts. Skin thickness and barrier accessibility are different in various areas so absorption rates will vary in different parts of the body. For example, hydrocortisone (a synthetic preparation used in the treatment of inflammations, allergies, and itching) is absorbed through the skin six times better on the forehead than on the arm, and 44 times better on the scrotum.
The physical condition of the skin is a significant variable. The skin of an infant or child is more permeable than an adult. The skin over the organs in decreasing order of permeability is genitals, head and neck, trunk, arms and legs. Skin abrasion allows a locally applied substance to come directly in contact with subcutaneous tissue and blood vessels. Absorption is at a much higher rate than in healthy skin. Inflammation leaves the skin leaky and allows larger molecules to be absorbed.
LL’s Magnetic Clay, the company that provides the Ancient Minerals
Magnesium Oil that I recommend include the main points discussed above
on their website.
They summarize that the factors that increase the amount of magnesium oil absorbed through the skin include:
Increasing the area of application Increasing the amount of time the application is left on the skin Increasing the frequency of application Varying the location of application, with areas such as the scalp and armpits exhibiting higher rates of absorption Increasing temperature of the area of application Applying to well-hydrated skin
They also make available a handy and informative guide to the proper
applications of their various Ancient Minerals products.
See my books and video on the practice of magnesium medicine. Books are
available as ebooks or as hardcopy from amazon.com
THERE IS CHRONIC LATENT MAGNESIUM DEFICIENCY IN APPARENTLY HEALTHY UNIVERSITY STUDENTS. Hermes Sales C1, et al;
Nutr Hosp. 2014 Jul 1;30(n01):200-204;
http://www.ncbi.nlm.nih.gov/pubmed/25137281
Magnesium Oil that I recommend include the main points discussed above
on their website.
They summarize that the factors that increase the amount of magnesium oil absorbed through the skin include:
Increasing the area of application Increasing the amount of time the application is left on the skin Increasing the frequency of application Varying the location of application, with areas such as the scalp and armpits exhibiting higher rates of absorption Increasing temperature of the area of application Applying to well-hydrated skin
They also make available a handy and informative guide to the proper
applications of their various Ancient Minerals products.
See my books and video on the practice of magnesium medicine. Books are
available as ebooks or as hardcopy from amazon.com
THERE IS CHRONIC LATENT MAGNESIUM DEFICIENCY IN APPARENTLY HEALTHY UNIVERSITY STUDENTS. Hermes Sales C1, et al;
Nutr Hosp. 2014 Jul 1;30(n01):200-204;
http://www.ncbi.nlm.nih.gov/pubmed/25137281
[2} The dose is the quantity of medicine to be administered at one time and the regimen is a strictly regulated program. The concentration of the applied dose, the surface area of the body, and the elapsed time the chemical is on the skin are the main considerations affecting absorption. As the concentration of a drug is increased, the total amount absorbed into the skin and body also increases. Increasing the surface area of the applied dose also increases penetration. Penetration occurs over time. The longer the substance is on the skin, the greater the chance for continued penetration. Chances for toxicity may occur when high concentrations of a drug are spread over a large area of skin
[3] Marks R M, Barton S P, Edwards C (1988). The Physical Nature of the Skin. Lancaster: MTP Press.
[3] Marks R M, Barton S P, Edwards C (1988). The Physical Nature of the Skin. Lancaster: MTP Press.